Investigation of alpha-synuclein aggregation and propagation in preclinical models for Multiple System Atrophy KU Leuven
Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by a rapid and aggressive decline in motor and autonomic functions. Currently there are no symptomatic or disease-modifying treatment options for MSA patients. The major neuropathological hallmark are deposits of alpha-synuclein (αSYN) protein aggregates, mostly glial cytoplasmic inclusions (GCIs) in oligodendrocytes, and less frequently in neurons.
Most ...