Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway Vrije Universiteit Brussel
Hypoxia is a common feature of the tumor microenvironment and a major cause of clinical radioresistance. During the last decades, several strategies to improve tumor oxygenation were developed such as breathing high oxygen content gas tinder hyperbaric conditions (3 atmosphere) and improving tumor perfusion by nicotinamide.. in combination with carbogen breathing and accelerated radiotherapy to counteract tumor repopulation (ARCON). Other ...