A combined structure-activity and biophysical investigation of the cyclic lipopeptide tolaasin, the virulence factor causing brown blotch disease Ghent University
Tolaasin, an 18 residue cyclic lipopeptide, is the main virulence factor of Pseudomonas tolaasii, and causes brown blotch disease in edible mushrooms. In addition to this antifungal activity, this secondary metabolite also display activity against Gram-positive, Gram-negative bacteria and cytotoxicity against MDA-MB-231 cancer cells. This wide targeting of cells is attributed to its membrane-lytic properties. While experimental data supports ...