Projects

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Center for Proteomics (CfP). University of Antwerp

Inge Mertens
Veterinary physiology and biochemistry, Biomolecular & Analytical Mass Spectrometry (BAMS), Center for Oncological Research (CORE)
The Center for Proteomics was founded about a decade ago as a UAntwerpen/VITO state-of-the-art mass spectrometry platform as a continuation of the former UAntwerpen CeProMa Core facility. Since 2017, the main focus of the UAntwerpen/VITO team was the use of proteomic approaches to identify biomarkers for early diagnosis of disease. Over the years, we have built up a multi-disciplinary team of lab technicians, mass spectrometry experts, ...

PEA histone modification proteomics Ghent University

Filip Van Nieuwerburgh
Department of Pharmaceutics, Department of Data analysis and mathematical modelling

Olink's groundbreaking proteomics panels help scientists discover human protein biomarkers. Proximity Extension Assay (PEA) technology measures up to 1463 unique proteins in 88 samples simultaneously, starting from less than 3 microliters from nearly any type of biological sample. Unique application domains are located where mass spectrometry (MS) based proteomics is suboptimal. Samples such as cerebrospinal fluid (CSF), microdialysis ...

Automated sample preparation for mass spectrometry-based proteomics using the DigestPro MSi instrument. Ghent University

Kris Gevaert
Department of Biomolecular Medicine, Department of Biochemistry, Department of Plant Biotechnology and Bioinformatics

Mass spectrometers are essential instruments for contemporary proteome analysis. Typically, proteins are digested into peptides prior to analysis. In our labs this crucial step is not automated, implying that variation is inevitably introduced by manual intervention. Here, by installing a robot for fully automated sample preparation we will increase the overall quality of our proteome research.

Using molecular signaling profile in white blood cells measured by highly-sensitive mass spectrometry (MS)-based proteomics in the differential diagnosis between major depressive disorder and bipolar disorder. University of Antwerp

Manuel Morrens
Collaborative Antwerp Psychiatric Research Institute (CAPRI)
Major depressive disorder (MDD) and bipolar spectrum disorder (BD) are severely debilitating mental disorders both characterized by an elaborate depressive symptomatology. In clinical reality, patients with either unipolar or bipolar depression often present with identical symptoms, resulting in a profile of clinically observable symptomatology that in itself remains insufficient for reliable and objective distinction and consequent correct ...

Proteomics Expertise Center Ugent Ghent University

Kris Gevaert, Dieter Deforce, Bart Devreese
Department of Biomolecular Medicine, Department of Biochemistry, Department of Pharmaceutics, Department of Biochemistry and microbiology

The Proteomics Expertise center groups expertise in (quantitative analysis) of proteins, their post-translational modifications en their interactions using mass spectrometry technology. It shares it facilities with researchers who need proteomics for functional research on proteins in the broad application field of Life Sciences (biomedical, food, environment)

Mining the Musa biodiversity for drought tolerance: allele discovery via integrated phenomics, proteomics and transcriptomics KU Leuven

Rony Swennen, Sebastien Carpentier
Division of Crop Biotechnics, Crop Biotechnics

Banana (Musa spp.) is one of the most produced fruits in the world, the production exceeded 122 million tons in 2013. For optimal production the crop requires: 1200–2690 mm water/year, depending on the agro-ecological zone. The limited genetic diversity in commercial plantations renders the crop extremely vulnerable for (a)biotic stress, like drought. However, worldwide a huge (uncharacterized) biodiversity is available, and we ...

In depth insight into the translatome using state-of-the-art proteomics and ribosome profiling, applications on different in vitro model systems. Ghent University

Wim Van Criekinge
Department of Data analysis and mathematical modelling, Department of Mathematical Modelling, Statistics and Bio-informatics

From a proteogenomic approach, bioinformatic tools will be developped to combine ribosome profiling and mass spectrometry results. These tools will secure exhaustive analysis of different translation features and controls. Experiments will be performed in cell lines and afterwards in embryoid and organoid bodies, as a proxy to in vivo tissue.

Applying proteomics and metabolomics for studying human trapezius myalgia and the effect of dry needling Ghent University

Barbara Cagnie
Department of Rehabilitation Sciences, Department of Rehabilitation Sciences and Physiotherapie

The first aim is to gain better insight in the pathophysiological processes of trapezius myalgia using a combination of microdialysis samples AND muscle biopsies in 25 patients with trapezius myalgia and 25 healthy subjects. The second aim is to more understand the effects of dry needling. Both acute and long term effects will be evaluated using a similar measurement protocol.

Unveiling the role of nuclear compartmentalisation in laminopathies with intelligent high content imaging and spatial proteomics. University of Antwerp

Winnok De Vos
Laboratory of cell biology and histology
Laminopathies are orphan diseases caused by mutations in the LMNA gene, which encodes A-type lamins. Recent evidence suggests that lamin defects cause abnormal nucleocytoplasmic compartmentalization. This feature is prone to contribute significantly to disease development in laminopathies, and may also play an important role in aging and certain cancers. With an eye on its medical potential, we want to expose the exact underpinnings of defective ...