Computational design of PolyOxoMetalates scaffolding proteins KU Leuven
Despite remarkable advancements in computational techniques, designing a functional protein from scratch remains very challenging and led scientists to adopt a `bottom-up' approach. Here, existing proteins are used as building blocks for functionalization with active sites or binding motifs.
Symmetric globular proteins stand out due to their inherent stability and compatibility with macromolecular assemblies.
This thesis first ...