Structural and morphological studies of heterotypic amyloid fibrils KU Leuven
Amyloid aggregates (insoluble fibrils rich in cross-beta-sheet structures) that spread to selective neuronal populations are a hallmark of neurodegenerative diseases and eventually cause neuronal death. We do not know the reasons for the selective vulnerability of neuronal cells, and I will address this problem at the molecular level with this project.
Amyloidogenic proteins contain aggregation-prone regions (APR) that drive their ...