Selective tyrosine phosphorylation of the PKD2 activation segment: a novel regulatory mechanism to achieve isoenzyme specific signaling within the protein kinase D family. KU Leuven
Most protein kinase enzymes occur as families of 2 up to sometimes >10 members. A fundamental question in kinase signaling remains: how can we explain the often very different cellular roles of members within a kinase family? The protein kinase D family consists of its members PKD1, 2 and 3 and is the focus of our attention in this project. These enzymes have important and often opposite roles in cancer (PKD1 inhibiting, whereas PKD2/3 ...