Non-viral gene transfer for the in vivo expression of therapeutic antibodies: a proof-of-concept study in cancer. KU Leuven
Antibodies are proteins that can selectively target cancer cells, and therefore present an attractive alternative to toxic chemotherapeutics. Despite their widespread clinical use in oncology, several problems remain, including production cost, rapid removal out of the body, and the subsequent need for repeated high-dose injections that can induce side effects. This project aims to address these problems by developing an antibody gene ...