Natural history and determinants of the burden of medial vascular calcification, using pseudoxanthoma elasticum as a model. Ghent University
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in Europe. This proposal addresses one of the hallmark changes in CVD and premature aging, namely medial vascular calcification (VCm). Considered a good target for diagnosis and prevention, a comprehensive understanding of the causes and consequences of VCm is lacking. We aim to contribute to this knowledge by studying a monogenic form of VCm, pseudoxanthoma elasticum ...