Projects

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IOF Proof Of Concept: Fight bacteria in humans and animals with the MICSTRIP concept Vrije Universiteit Brussel

Hugo Thienpont
Brussels Photonics Team, Applied Physics and Photonics, Technology Transfer & Interface, Industrieel Onderzoeksfonds
Because of the growing concern associated with antibiotic medication and resistance, the World Health Organization emphasizes the need to have effective, rapid, easy-to-use and low-cost diagnostic tools. Since none of the current antibiotic susceptibility testing methods comply with the current needs, a new photonics-based concept was worked-out in a collaboration between Universiteit Antwerpen (Medical Microbiology and Product Development) and ...

IOF Proof of concept project: Innervate 3D ultra-stretchable electronics low volume fabrication Hasselt University

Wim DEFERME, Steven NAGELS
Engineering Materials and Applications
Spin-off project Innervate manufactures electronic circuits that stretch like rubber bands through an innovative combination of ultra-stretchable connections and off-the-shelf components. The next step in maturing Innervate is to create a first implementation of novel concepts for the low volume production process. The means of this Proof of Concept project continue on earlier identified opportunities from prior Concept funding. The project ...

In-vivo proof of concept of microbubbles based non-invasive dosimetry for radiotherapy treatment. KU Leuven

Jan D'hooge
Cardiovascular Imaging and Dynamics, Laboratory of Experimental Radiotherapy, Physics, Kulak Kortrijk Campus

Cancer remains a major public health problem in the world which necessitates the need for further technological innovation towards effective treatment strategies. Next to surgery and chemotherapy, an important treatment option is radiotherapy in which tumor cells are destroyed by ionizing radiation. Although modern radio therapeutic treatment strategies have become very efficient by reducing radiation to adjacent (healthy) tissue whenever ...

Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer KU Leuven

Christophe Dooms
Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE)

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of radiation observed at distance from the ...

A proof of concept study for a novel mechanism of action to combat osteoporosis by inhibiting osteoclastogenesis Ghent University

Dirk Elewaut
Department of Translational Physiology, Infectiology and Public Health, Department of Internal medicine

Excessive bone resorption by osteoclasts can lead to disability as well in inflammation induced bone erosion such as Rheumatoïd Arthritis as in non-inflammation dependent bone diseases such as postmenopausal osteoporosis. We have shown that sialoadhesin has a role in osteoclastogenesis as its deficiency or blocking inhibits osteoclastogenesis ex vivo in mouse and human and in vivo in mice, either non-diseased or during arthritis. Based on ...

Exploring the role of non-coding variation in inherited retinal dystrophies: NMNAT1 regulatory mutations as a proof of concept Ghent University

Elfride De Baere
Department of Pediatrics and medical genetics

Inherited retinal dystrophies (RDs) are a major cause of early-onset blindness worldwide. The

currently known genetic defects account for ~50% of RD cases and are mostly located in the coding

portion of the genome. However, there is accumulating evidence that a large proportion of

mutations reside in non-protein-coding regions, the so-called U+201Cunk DNAU+201D Thus far, several deepintronic

mutations have ...

Hospi Adventure: Proof of concept and business model for the development of a game that prepares kids for hospitalization. Hasselt University

Applied Computer Science Lab
Children get hospitalized for treatment of a decease, for examination, for a surgical operation or for further observation. Every one of these reasons can cause a very stressful situation for parent and child. Dit IOF-research project builds on a feasibility study based on the premise that good information provision to hospitalized children using the right methodology (applied by all involved parties, parents, hospital workers and schools) will ...

Development of an evidence based proof of concept care path for Non-Alcoholic Fatty Liver disease in Flanders. Hasselt University

Geert ROBAEYS
Immunology & Infection
An increasing percentage of people worldwide have or are at risk to develop non-alcoholic fatty liver disease (NAFLD). NAFLD can evolve to non-alcoholic steatohepatitis complicated by liver cirrhosis and even hepatocellular carcinoma (HCC). There are no accurate and high quality data on prevalence of the disease and its different stages and subtypes, how NAFLD patients with fibrosis are referred, neither on the evolution of NAFLD patients in a ...

Proof of concept for a decision support system to reduce the occupational risks of seafarers due to air quality. University of Antwerp

Serge Demeyer
Antwerp Cultural Heritage Sciences (ARCHES), AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation), Antwerp Maritime Academy, Artesis Plantijn Hogeschool Antwerpen, Antwerp Systems and software Modelling (AnSyMo)
This project aims to explore the basic principles of a decision support system that allows the continuous monitoring of the working conditions of seafarers. For this purpose, it wants to (1) measure several environmental parameters simultaneously (e.g., temperature, light, NO2, O3, etc.), (2) convert the measurements into a global air quality, and (3) visualize the evolution in air quality sothat seafarers can easily evaluate the working ...