Metabolic and epigenetic interplay in neural progenitor cells: investigating neurodevelopmental disorders associated with impaired neural progenitor cell expansion (MEPIcephaly). KU Leuven
Neurodevelopmental disorders (NDD) result in variable neurological and psychological impairments. Here, we focus on microcephaly-associated NDDs that are characterized by a critical decrease in brain size, primarily caused by impaired neural stem and progenitor cell (NPC) expansion in the fetal neocortex. Previously, gene mutations associated with abnormal cell cycle progression, centrosome formation and DNA repair have been identified, yet a ...