Tissue engineering of human muscle: proof of principle for using iPSC-derived myogenic precursor cells and a prevascularization strategy. KU Leuven
We will expand further on an existing 3D human muscle tissue engineering method. Current state of the art is that such muscle can be made up of aligned myofibers in an extracellular matrix. The size of these muscles that can be reached without inducing cell death in the inner part is limited due to the passive diffusion limit of oxygen and nutrients to the myofibers. By addition of endothelial precursor cells, we have shown it is possible to ...