Projects
Investigating current gaps in time-dependent inhibition (TDI) and induction drug-drug interactions (DDIs). A focus on CYP3A4 and non-CYPs drug metabolizing enzymes (DMEs). KU Leuven
The reliable prediction of drug-drug interactions (DDIs) early during drug discovery and development is crucial for an efficient and successful drug development process in the pharmaceutical industry. However, remarkable knowledge gaps exist for specific DDI mechanisms, including: (i) time-dependent ('suicide') inhibition (TDI) of drug metabolising enzymes, and (ii) drug-mediated induction of drug metabolising enzymes. This project will ...
Multiscale Characterization of Exchangeable Potassium Content in Soil to Remediate Agricultural Land Affected by Radioactive Contamination using Machine Learning , Soil Spectroscopy and Remote Sensing. KU Leuven
The ability to characterize rapidly and repeatedly exchangeable potassium (Kex) content in the soil is essential for optimizing remediation of radiocaesium contamination in agriculture. Wet chemistry can accurately characterize Kex content in soil but is cost and time prohibitive. On the other hand, infrared spectroscopy does not allow for accurate characterization of Kex when applied to small, local soil spectral libraries. Last, the ability ...
Adaptive Fused Filament Fabrication (AF3) KU Leuven
Climate change experiments in Arctic and Antarcticpolar desert soils - ExPoSoils Ghent University
The Arctic and parts of Antarctica are experiencing very rapid climate and environmental changes. Earth system models further predict increasing temperatures and changing precipitation patterns in the 21st century as a result of the polar amplification of global warming. It can be expected that these changes will affect the biodiversity and functioning of polar ecosystems, yet the resilience of these habitats and their vulnerability to change ...
High efficiency, high power density, cost effective, scalable and modular power electronics and control solutions for electric vehicles Ghent University
Focused on BEV architectures with distributed multiple wheel drives, and, specifically, in-wheel powertrains, HighScape will explore the feasibility of a family of highly efficient power electronics components and systems, and including integrated traction inverters, on-board chargers, DC/DC converters, and electric drives for auxiliaries and actuators. The proposed solutions will be assessed on test rigs and on two differently sized BEV ...
Cell adhesion molecules in severe asthma: unravelling the role of DEL-1 Ghent University
Asthma is a chronic inflammatory airway disease that affects around 334 million individuals worldwide and has a significant economic burden. Patients with severe asthma have persistent respiratory symptoms, reduced quality of life and frequent exacerbations, which require treatments with oral corticosteroids, hospitalization and may even be fatal. Despite important breakthroughs in the treatment of severe asthma, there is an unmet medical ...
Applications of deep learning for cancer genomics KU Leuven
Since its selection as the method of the year in 2013, single-cell technologies have become mature enough to provide answers to complex research questions, including cancer genomics. With the growth of single-cell profiling technologies, thousands of genomic features can be measured simultaneously on tens or hundreds of thousands of individual cells in a single experiment. This allows us to characterize cell states in heterogeneous tumors at ...
Flexibele, voorspellende en hernieuwbare elektrochemische gereedschapskist op elektriciteit Voor een duurzame transitie van de op katalysatoren gebaseerde Europese chemische industrie KU Leuven
The FIREFLY project rises to the sustainable evolution of the catalyst-based chemical industry, towards its electrification and reduced third-party dependence on metals and fossil energy. The controversial sustainability challenges and opportunities in catalysts recycling/production and catalyzed chemical processes motivated the synergy of 16 partners proposing the FIREFLY concept, relying on the development of:
i) Electro-driven ...