Projects
Novel sampler for ambient ionization high-resolution mass spectrometry (AIMS)-based metabolomics and its application in pediatrics precision medicine. Ghent University
There is an unmet need for samplers permitting rapid sample processing for a.o. precision medicine metabolomic fingerprinting. AIMS-based metabolomics allows to record mass spectra from samples in their native environment without the need for chromatographic separation. Existing samplers are not customized for this approach or matrix is burned along with the sample leading to interferences and contamination. In this StartTT we aim to deliver ...
Empowering precision medicine. An exploration University of Antwerp
Inherited cardiac arrhythmias: identification of novel genes and development of a new diagnostic tool for translating genetic diagnosis into precision medicine. University of Antwerp
A precision medicine approach for canine degenerative myelopathy combining genetic and epigenetic alterations Ghent University
This project aims to introduce precision medicine and epigenetics research in the canine neurogenetics field. Practically, canine degenerative myelopathy will be studied with MBD-seq to identify differentially methylated regions associated with disease progression. This will be followed by the writing of a general statistical analysis framework in R that accurately predicts clinical age ofonset for this disorder.
Precision medicine in inherited blindness using integrated omics in human and animal models Ghent University
This multidisciplinary project aims (1) to decipher cis-Âregulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-Âbased treatments of novel targets, ultimately resulting in precision medicine ...
Bioinformatics for a high-throughput deep mutational scanning protein-protein interaction assay: turning a prototype into a precision medicine toolbox Ghent University
This proposal contributes to the development of a high-throughput method to characterize the impact of nearly every mutation on specific protein-protein interactions. After bioinformatics-driven experimental optimization, this method will be applied to tumor-driver protein interactions (TP53, PTEN, PIK3R1) and results compared to large-scale tumor mutation and gene expression data. This will allow to demonstrate the major relevance for ...
Advanced 3D Complex Tissues BioAssembly Platform for Precision Disease Modeling, Drug Discovery and Regenerative Medicine (3D-BioBOT) KU Leuven
European Training Network for developing Smart neurOmonitoring tosupport PRecision medicine in Acute central Nervous Injury KU Leuven
Analysis of circulating cell-free tumor DNA from lung tumors and diffuse large B-cell lymphomas for early detection and selection of patients for precision medicine Ghent University
The first step in the therapy of lung and hematological cancers is adequate diagnosis. Analysis of circulating tumor DNA by massively parallel sequencing is a non-invasive approach for early detection without a tissue biopsy. This approach is also promising for the development of a test for selection of cancer patients who could benefit from immunotherapy and precision medicine.