Projects
Natural variation in temperature sensitivity of male meiosis and pollen development. Ghent University
High and low temperatures or sudden temperature shifts during flowering cause reduced fertility due to various defects during meiosis and gamete formation. This project will explore the natural variation in temperature sensitivity in order to identify genetic factors and alleles responsible for defects in male meiosis and reduced fertility in Arabidopsis and rice during temperature stress.
Expertise-onderzoek bosbeheer en koolstofboekhouding: Kwaliteitsvolle uitvoering van onderzoek inzake abiotiek van geselecteerde, voor kamsalamander kansrijke poelen in Zemst en de Vlaamse Ardennen Ghent University
Pooled CRISPR/Cas9 screen in human stem cell-derived motor neurons to identify new therapeutic targets for amyotrophic lateral sclerosis (ALS) KU Leuven
Amyotrophic lateral sclerosis (ALS) is the most prevalent adult-onset neurodegenerative disorder characterized by the selective death of motor neurons which cause the death of the patients within 2 to 5 years after first diagnosis. There is no cure available. Cell reprogramming technology enabled the generation of human induced pluripotent stem cells (hiPSCs) from somatic cells of ALS patients to model ALS in a dish. CRISPR/Cas9 genome ...
Identification of new psychoactive substances and their metabolites through the analysis of pooled urine and wastewater. University of Antwerp
Collen Francqui Start-up Grant 2021 - 2024 Werend Boesmans Hasselt University
The evolution of prehistoric occupation in Sandy Flanders from an environmental perspective Ghent University
The present project aims at an interdisciplinary, GIS-related study of the land-use systems in Sandy Flanders (NW Belgium) from the late Stone Age (ca. 13,000 uncal. BP) until the Roman period. The main aim is to investigate the role and impact of the environment (vegetation, climate, soil) on the preshistoric settlement system in a multitemporal framework. The project will focus on 3 to 4 core-areas, 2 with a low site-density ("empty ...
T cell plasticity in health and disease. KU Leuven
Appropriate immune responses are the result of a delicate balance between effector T cells, which fight infections and cause symptoms of inflammation, and regulatory T cells, which dampen the immune response once the pathogen has been cleared. Both cell types can temporarily or permanently adopt features of the other, a process known as cellular plasticity. This plasticity can be advantageous, however the process can also go wrong, leading to ...
Precision medicine in inherited blindness using integrated omics in human and animal models Ghent University
This multidisciplinary project aims (1) to decipher cis-Âregulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-Âbased treatments of novel targets, ultimately resulting in precision medicine ...
Molecular neurobiology of aging. KU Leuven
Aging is the primary risk factor for many human pathologies such as cardiovascular diseases, cancer, diabetes and neurodegenerative disorders. Therefore, societal aging comes with an emotional and financial burden of age−related health issues and diseases, most of which go without a cure. While vast amounts of money are being spent on the study of aging−related diseases, surprisingly little investments have been made to sort out the ...