Projects
The elucidation of pathogenesis and modes of inheritance of catecholaminergic polymorphic ventricular tachycardia using cardiac optical imaging in zebrafish. University of Antwerp
Functional engineering of polymorphic nanomaterials KU Leuven
The role of dopamine D4 receptor ubiquitination and functional differences between the polymorphic receptor variants Ghent University
The ubiquitination of the dopamine D4 receptor (DRD4), a G protein-coupled receptor (GPCR), is enhanced upon its interaction with a BTB-Kelch protein, KLHL12. We have shown that the KLHL12-induced DRD4 polyubiquitination does not play a key role in receptor degradation. In the current research we are investigating the role of ubiquitination in receptor signaling.
Unraveling the possible epigenetic basis for phase polymorfism in the desert locust, Schistocerca gregaria. KU Leuven
Causes and consequences of variation in queen number and polydomy in a highly polymorphic and isolated Formica rufa population Ghent University
Recent genetic analyses in an isolated wood ant (Formica rufa)population in the Sint-Sixtus forest revealed strong variation in relatedness among workers, and in colony structure and number of queens ruling a colony. This project aims to determine udnerlying causes and consequences of this variation. Hyptheses will be tested through a combination of behavioural observations, morphometric measurements, experimental manipulations and genetic ...
The role of dopamine D4 receptor ubiquitination and functional differences between the polymorphic variants. Ghent University
The dopamine D4 receptor is a G protein- coupled receptor. We have shown that this receptor is ubiquitination upon interaction with KLHL12 (a Kelch-BTB protein) and in this project we will investigate what the functional role of this receptor ubiquitination is.