Exploring the Sequence and Functional Landscapes of Natural and Engineered Polymerases KU Leuven
Xenobiotic nucleic acids (XNAs), chemical analogs of nature’s only genetic polymers (DNA and RNA), are not only able to store and propagate genetic information, but also broaden the chemical diversity of genetic polymers and their biotechnological and pharmaceutical applications. However, the synthesis of XNA is limited by the low efficiency and lack of selectivity of the current generation of engineered XNA polymerases. This project aims to ...