Projects
Does angiopoietin-Tie signaling affect podocyte integrity in kidney glomeruli? Ghent University
We recently discovered TIE1 and TIE2 receptor signaling on kidney glomerular podocytes, which are important cells of the glomerular filtration barrier. To investigate if TIE-receptors regulate glomerular integrity, we will investigate the role of this signaling system on podocyte function, i.e. survival, migration, proliferation and permeability. In addition, we will investigate the downstream
signaling pathways regulated by ...
Mechanism of podocyte damage in the development of sickle cell nephropathy KU Leuven
Several factors including genetic ones such as APOL1 risk variants (G1 and G2) and HMOX1 GT repeats have been shown to influence the development of sickle cell nephropathy (SCN). We have previously shown that APOL1 high risk genotypes are associated with SCN in our steady-state sickle cell disease (SCD) paediatric population from the Democratic Republic of Congo (DRC) (unpublished data). However, data on associations between these genetic ...