Acquired NK cell dysfunction and role of IL-18 in inflammatory diseases associated with secondary hemophagocytic lymphohistiocytosis KU Leuven
Secondary hemophagocytic lymphohistiocytosis (sHLH), a hyperinflammatory syndrome with severe morbidity and potential mortality, can develop as a complication of a variety of autoimmune and autoinflammatory diseases. The reason patients develop sHLH is unknown, hampering timely diagnosis and treatment. We aim to provide evidence for the hypothesis that sHLH results from acquired defects in natural killer (NK) cell activities, impairing their ...