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Generation and characteristics of procoagulant platelets KU Leuven

Claudia Tersteeg
Cardiovascular Sciences, Kulak Kortrijk Campus

Upon activation, a subpopulation of platelets adopts a necrotic procoagulant phenotype, which is characterized by bioenergetic failure of the cell. The molecular events underlying the formation of procoagulant platelets include calcium cytotoxicity and reactive oxygen species; both facilitate the cyclophilin D (CypD)-dependent formation of the mitochondrial permeability transition pore, leading to a decreased mitochondrial membrane potential ...

The platelet lipidome, a key regulator of platelet inflammatory andprocoagulant functions during sepsis KU Leuven

Claudia Tersteeg
Cardiovascular Sciences, Kulak Kortrijk Campus
Apart from their well-recognized role in arterial or venous thrombotic diseases, platelets are also activated during severe infection (sepsis) and play a key role in controlling microthrombosis and inflammatory response, a process called thromboinflammation. Lipids are the precursors of inflammatory mediators that have a recognized impact on sepsis outcome. Their platelet content and composition can be modulated by a specific ...

Platelets from tissue culture, regenerative medicine for durability and customized transfusion Ghent University

Veerle Compernolle
Department of Diagnostic Sciences, Department of Clinical chemistry, microbiology and immunology

  ; In the future, platelets will be grown in bio -incubatoren. Such platelets will be compared in detail in this project with the current clinical gold standard: platelets prepared from whole blood donations. The objective is to at pre-clinical level, to demonstrate the efficacy of in vitro-generated platelets. Our data will be used to support clinical trials (2018-2019).

Unveiling procoagulant platelets: mechanistic insights and an emerging therapeutic target KU Leuven

Claudia Tersteeg
Cardiovascular Sciences, Kulak Kortrijk Campus, Chemistry, Kulak Kortrijk Campus

Platelets are primarily recognized for their crucial role in preventing blood loss and stop bleeding during hemostasis. Their activation occurs through receptor interactions with the exposed subendothelial matrix or agonists released by other platelets. Subsequently, platelets aggregate to form a plug, and a subset adopts a procoagulant phenotype. New findings in the formation of procoagulant platelets reveal differences among different ...

Genome medicine for bleeding, thrombotic and platelet disorders KU Leuven

Kathleen Freson
Centre for Molecular and Vascular Biology
Platelets, the 2nd most abundant cell in the blood, play an essential role in cardiovascular disease. Inherited bleeding, thrombotic and platelet disorders (BTPD) are characterized by marked genetic heterogeneity. The list of genes involved in the regulation of platelet formation and function and bleeding or thrombosis has been growing rapidly to almost 100 genes since the introduction of high-throughput sequencing (HTS) approaches in research. ...

Platelet fragmentation and the formation of platelet-derived extracellular vesicles KU Leuven

Claudia Tersteeg
Cardiovascular Sciences, Kulak Kortrijk Campus
Circulating extracellular vesicles (EV) are derived from various cell types, of which the majority is derived from platelets. The biological cargo of platelet-derived EV includes a variety of biological molecules, such as surface receptors, coagulation proteins and cytokines. There is increased evidence that EV play an important role in regulating thrombotic and hemostatic processes, for example through mediating intercellular communication ...

Genetic analysis, manipulation and correction of molecular pathways of blood platelet formation and function. KU Leuven

Marc Hoylaerts
Centre for Molecular and Vascular Biology, Chemistry, Kulak Kortrijk Campus
Megakaryocyte differentiation and thrombopoiesis are complex and incompletely understood processes. It is our goal to unravel new molecular megakaryocyte pathways implicated in cellular differentiation and platelet formation and to study unknown aspects of platelet function. In view of the multitude of molecular pathways in platelets, platelets will also be studied extensively, as reporter cells to investigate pathway dysfunctions, relevant for ...

(Epi)Genetic studies and system biology approaches to characterize rare inherited bleeding and platelet disorders: from patient studies to basic biology to cl inical applications KU Leuven

Kathleen Freson
Centre for Molecular and Vascular Biology

In this OT project, (epi)genetic large-scale studies in combination with functional in vitro studies will be used to characterize patients with “rare inherited Bleeding and Platelet Disorders (BPDs)”. (Epi)Genetic studies and system biology approaches to characterize rare inherited bleeding and platelet disorders: from patient studies to basic biology to clinical applications.

The why, when and how of platelet GPIbα ectodomain shedding Ghent University

Hendrik Feys
Department of Diagnostic Sciences

The role of GPIbα shedding and glycocalicin release by ADAM17 is unknown. During this mandate, we will investigate where and when GPIbα shedding occurs in models of haemostasis. The role of glycocalicin will be further unraveled. Neutrophils strongly bind to GPIbα and this project will investigate how (trans)migration of neutrophils is inflenced by glycocalicin using models of haemostasis.

Infective endocarditis – role of the coagulation system and anti-platelet prophylaxis in patients at risk. KU Leuven

Ruth Heying
Cardiovascular Developmental Biology
Infective endocarditis (IE) is a major problem in patients after heart valve replacement. Preventive treatment with anti-platelet drugs has been partially introduced in clinical practice while its benefit to reduce the risk of IE remains under discussion.This proposal combines the clinical, multidisciplinary expertise gained from diagnosis and treatment of IE patients with complementary basic research on platelet activation, bacterial ...