MEMCLIP: A comprehensive chemical-biology approach to understand the bioactivity of Pseudomonas cyclic lipopeptides on eukaryotic membranes Ghent University
The activity of cyclic lipopeptides, produced by Pseudomonas bacteria and chemically synthesized analogues will be tested in a standardized way on human (healthy and cancer) cells, plant cell suspensions and fungal cells. Using a combination of biological and (physico-)chemical methods we will test the hypothesis that in all these eukaryotic cells, these lipopeptides act on lipids in the cell membranes.