Publications
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Photothermal nanomaterial-mediated photoporation Ghent University
Response surface methodology to efficiently optimize intracellular delivery by photoporation University of Antwerp
Photoporation is an up-and-coming technology for the gentle and efficient transfection of cells. Inherent to the application of photoporation is the optimization of several process parameters, such as laser fluence and sensitizing particle concentration, which is typically done one factor at a time (OFAT). However, this approach is tedious and runs the risk of missing a global optimum. Therefore, in this study, we explored whether response ...
Towards minimally invasive delivery of large molecules into human T cells by photoporation with polydopamine nanosensitizers and photothermal nanofibers University of Antwerp
Adoptive T cell transfer has demonstrated remarkable clinical success in the treatment of hematological malignancies, holding great potential to transform cancer care. Development of such novel therapies requires ex vivo T cell engineering with a synthetic tumor antigen-specific receptor. To address the complexities and high costs associated with viral vector-based T cell manufacturing, alternative non-viral approaches have been actively ...