Engineering of universal iPSC-derived therapeutic cells by nanofiber photoporation. Ghent University
With cancer cases rapidly rising, there is a dire need for highly efficient therapies such as CAR-T cell therapy. Currently, the production of CAR-T cells involves a long and costly manufacturing process, notably because of its autologous nature and the use of viral vectors, which hampers accessibility of the treatment to patients. To solve these limitations, iPSC-derived allogeneic CAR-T cells engineered in a non-viral manner is a promising ...