The DNA methylome in Common Variable Immunodeficiencies (CVID): a comprehensive study characterizing its heterogeneity and its role in disease subclassification Ghent University
Common variable immunodeficiencies (CVID) are the most common primary immunodeficiency. The dysfunctional immune system of CVID patients is unable to protect them against infections. A subgroup of the CVID patients develop a severe disease with distinct comorbidities, associated with a poor outcome. In the majority of the CVID no monogenic cause is found. Flow cytometry (FCM) and to a lesser extent genetic analysis are currently used to ...