Projects
Development of novel techniques for the simulation of solid-liquid phase change problems Ghent University
Thermal Energy Storage is key for the development of a sustainable energy system in the EU. Current solid-liquid phase change models lack accuracy with a sinking or floating solid phase. This project aims at developing new CFD based modelling techniques for close contact melting in phase change materials. The technique will be used to investigate melting in porous structures.
Chalcogenide Heterostructures as Nanocomposite Phase Change Materials Ghent University
The unique characteristics of phase change materials make them applicable in several emerging fields such as memory and photonics. Heterostructures are a promising way to improve the efficiency and performance of phase change devices by confining heat to a nanometer domain. Structural, thermal and optical characterization will be used to explore new materials for use in these structures.
PEACE V: a randomized phase III trial for the Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM) Ghent University
Prostate cancer patients being confronted with a limited nodal recurrence are generally treated with palliative lifelong systemic androgen deprivation therapy with an important negative impact on the quality of life. The current study wants to establish a new standard of care for these patients exploring the potential of local treatments, improving progression-free survival and quality of life.
Simulation of image formation in X-ray phase contrast tomography University of Antwerp
HavePhAIth: Human Phage therapy using AI to design phage cocktails against ESKAPE pathogens KU Leuven
A pipeline for phage lysins targeting multidrug-resistant Staphylococcus pseudintermedius in canine pyoderma and bacterial otitis externa Ghent University
Phage lysins are enzymes produced by bacterial viruses (phages) at the end of their replication cycle. These enzymes degrade the peptidoglycan layer, resulting in lysis of the infected cell and release of the newly matured phage particles. Recombinantly produced and purified phage lysins constitute a novel class of enzyme-based antibiotics. These are currently developed for human therapy with the first clinical trial showing superiority ...
Understanding the evolutionary dynamics of phage lysin configurations as a driver for new enzyme-based antibiotics Ghent University
(Bacterio)phage lysins are developed as enzyme-based antibacterials with an outstanding potential to fight antibiotic resistance. The lead lysin is currently evaluated under a clinical phase III trial. What sets apart lysins from all other classes of antibacterials is their modularity and the opportunities that emerge thereof to customize their antibacterial properties. Lysins therefore represent a true new class of antibacterials. Increasing ...