Projects
HavePhAIth: Human Phage therapy using AI to design phage cocktails against ESKAPE pathogens KU Leuven
Implementation of Personalized PHAGE therapy to combat difficult-to-treat infections (IP-PHAGE) KU Leuven
Phage therapy for improving sludge quality: towards healthier and more energy-efficient water treatment HOGENT
MAGICoPHAGE: magistral cocktail of phage. KU Leuven
Phage therapy represents an alternative to conventional antibiotic therapy, especially in multi-resistant infections. It is an antibacterial approach whereby bacterial viruses (‘phages’) infect and lyse bacteria to cure or prevent diseases. Phages in the environment are constantly evolving to overcome bacterial resistance and thus offer a functionally limitless, sustainable, source of new antimicrobials. Despite this, major obstacles for the ...
Quantitative phage control for safe treatment of bacterial invasive species in cystic fibrosis patients HOGENT
Phage RealTime Amplification for Molecular Enumeration HOGENT
A pipeline for phage lysins targeting multidrug-resistant Staphylococcus pseudintermedius in canine pyoderma and bacterial otitis externa Ghent University
Phage lysins are enzymes produced by bacterial viruses (phages) at the end of their replication cycle. These enzymes degrade the peptidoglycan layer, resulting in lysis of the infected cell and release of the newly matured phage particles. Recombinantly produced and purified phage lysins constitute a novel class of enzyme-based antibiotics. These are currently developed for human therapy with the first clinical trial showing superiority ...
Oncocidia_the novel anticancer therapy: phase 0 clinical study. KU Leuven
Cancer residue, common after current therapies, remains a culprit for recurrence and patient death. To solve this problem, the group of Prof. Y. Ni at KU Leuven has developed a new dual targeting anticancer strategy, called Oncocidia. It is based on the subsequent injection of two compounds – a vascular disruptive agent and a radiolabeled necrosis-avid compound- which have a highly synergistic effect. The therapy has been extensively tested ...