Publications
Effects of pressure/temperature treatments on stability and activity of endogenous broccoli (Brassica oleracea L. cv. Italica) myrosinase and on cell permeability KU Leuven
Comparison of supercritical fluid chromatographic methods to predict the skin permeability of pharmaceutical and cosmetic compounds Vrije Universiteit Brussel
Supercritical fluid chromatography (SFC) was explored as an alternative for liquid chromatography to predict the skin permeability of pharmaceutical and cosmetic compounds. Nine dissimilar stationary phases were applied to screen a test set of 58 compounds. The experimental retention factors (log k), in addition to two sets of theoretical molecular descriptors, were applied to model the skin permeability coefficient. Different modelling ...
Predicting skin permeability of pharmaceutical and cosmetic compounds using retention on octadecyl, cholesterol-bonded and immobilized artificial membrane columns Vrije Universiteit Brussel
In this study, the retention on three types of columns, an immobilized artificial membrane (IAM), a cholesterol-bonded and an octadecyl (C18) column, was applied for the prediction of skin permeability. The first two columns are biomimicking ones, which have certain components of the skin bound to the stationary phase, and were applied in HPLC, while the sub-2 µm C18 column was studied in UHPLC because of its fast features. Fifty-eight ...