DETECTIVE : Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems. Vrije Universiteit Brussel
Emphasis was given to systematic ...
1) Because existing anti-inflammatory IBD therapies do not reduce the risk of fibrosis, the
innovation delivered by FIBRO-TARGET twofold. First, we will be novel and preclinical
provide validated targets for small molecule and / or biological development
molecules as drug candidates against fibrosis complications in IBD patients. Second
FIBRO-TARGET wants to ...
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established neurosurgical therapy to treat advanced Parkinson’s disease (PD). To maximize therapeutic effect, optimal DBS settings must be carefully selected for each patient. Unfortunately, optimal therapeutic effect is not always achieved. New technological advances in the DBS field such as directional leads and DBS devices with multiple current sources have exponentially expanded ...
genes associated with high to intermediate breast cancer risks, like BRCA1/2, ATM, CHEK2, PALB2, are all involved in the DNA damage response pathway. Mutations in these genes may therefore not only contribute to genomic instability and cancer but also to a radiosensitive phenotype, increasing the carcinogenic risk of mammography screening in mutation carriers. The aim of this project is (i) to elucidate if women harbouring a germline mutation ...
The clinical development of novel analgesics is facing extreme challenges. The highest attrition is caused in the proof-of-concept phase (phase II) due to lack of efficacy and/or safety in the target population. Lack of efficacy is most prominent in CNS related diseases, including chronic pain conditions, in which animal models of efficacy often are insufficient to predict target engagement and efficacy in patients. A potential approach for ...
Cancer cells can divide, invade and metastasize, but the realizationof these activities is largely dependent on the resistance and collaboration of the tumor environment. We investigate whether mechanisms of cellular secretion, essential for communication between cancer cells and their environment, are potential prognostic biomarkers. Strategies suppressing secretion based mesenchymal-epithelial interactions have possible therapeutic ...
The aims of this PhD–project were to a) determine screening criteria for HNF1B analysis in patients with congenital anomalies of kidney and urinary tract (CAKUT), b) generate an infrastructure to facilitate longitudinal follow–up of a birth cohort of former extremely low birth weight (ELBW) neonates and subsequent data pooling with other cohorts and c) to use this infrastructure to study the consequences of preterm birth and ...