Projects
G-protein-coupled receptors (GPCRs) of human pathogenic fungi and their role on growth, morphogenesis and virulence KU Leuven
Human pathogenic fungi, such as Candida albicans and Aspergillus fumigatus are important human fungal pathogens. C. albicans normally lives as a commensal in our intestinal tract or in the oral mucosa. In immunocompromised persons, however, it can cause a number of diseases ranging from superficial infections to subcutaneous as well as systemic infections, often resulting in death. Aspergillus fumigatus is a fungus that lives in the ...
Molecular Characterization of glucose sensing and signaling mechanisms in the pathogenic fungi Candida albicans and Aspergillus fumigatus. KU Leuven
Identification of autoantibodies with pathogenic impact on spinal cord injury. Hasselt University
Unraveling the paradigm of opposing phenotypes due to pathogenic variants in the FBN1 gene. University of Antwerp
Unravelling the pathogenic mechanism behind influenza associated aspergillosis KU Leuven
Invasive pulmonary aspergillosis (IPA) is a life-threatening infection occurring mainly in immunocompromised patients. However, recently severe influenza infection gains a foothold worldwide as a novel emerging risk factor for IPA in critically ill patients. Despite notable advances in clinical observations, the mechanism underlying influenza-associated pulmonary aspergillosis (IAPA) remains unknown. Therefore, this project aims to provide ...
Uncovering the pathogenic role(s) of ABCA7 transporter in Alzheimer’s disease KU Leuven
ABCA7 is now considered as an important genetic determinant for late-onset Alzheimer’s disease (AD). ABCA7 PTC mutations and pathogenic expansions can be identified in up to 11% of Caucasian AD patients, and one single PTC variant occurs in 9-15% of African American AD patients, but how these variants affect structure and function of ABCA7, and promote pathogenesis, remains largely unknown. Here, we will investigate how these transporters ...