Projects
Spectator Ligand Effects in Palladium Catalysis (SPEPCAT). Ghent University
The design and understanding of well-defined organometallic architectures are key to modern catalysis. The focus of this project is the need for ever active and longer living complexes leading to the formation of C-C and C-N bonds. We address these challenges by developing a novel paradigm
in well-defined palladium catalysis and investigating the stabilizing/reactivity role of supporting “spectator” ligands.
A dance with palladium: exploration of propargylguanidines in tandem cyclization / C-H activation processes for the synthesis of kealiinine analogues and related medium-rings. KU Leuven
The new alkaloids kealiininesA-C, isolated in 2004 by Proksch and co-workers from the marine sponge Leucetta chagosensis, display a typical 2-aminoimidazole skeleton.They have been shown to posses a naphthimidazole moiety, which could be regarded as a conformationally constrained variant of the related naami(di)ne alkaloids, which possess interesting pharmaceutical properties. Although kealiinineA showed promising bioactivity, no profound ...
Search for a Treponema pallidum Antigen Test (SeTPAT) project Treponema pallidum-specific proteomic changes in patients with incident syphilis infection: an observation study in Belgium Institute of Tropical Medicine
A Directed Search for a Treponema pallidum Antigen Test Institute of Tropical Medicine
Palladium-Catalyzed Cascade Cross-Couplings towards Complex Heterocycles KU Leuven
This thesis investigates the palladium-catalyzed domino sequence of intramolecular carbopalladation of olefins tethered to aryl halides, forming living σ-alkyl-Pd(II) species followed by palladium migration, C-H activation, or nucleophilic capture to construct sets of heterocycles. In this thesis, reactions were carried out under either thermal or visible light irradiation conditions. Generally, the functionalization of the remote C-H bond is ...
New avenues for small heterocycles: Expanding the horizon of intra-/inter-molecular trapping of in situ generated transient σ-alkyl-/vinyl-palladium(II) species. KU Leuven
New avenues for small heterocycles: Expanding the horizon of intra-/inter-molecular trapping of in situ generated transient -alkyl-/vinyl-palladium(II) species. KU Leuven
Transition metal catalysis lies at the heart of modern innovative science. To expand this area in organic synthesis, the challenge is to identify novel strategies for the formation of organo-metallic intermediates under mild conditions, and to discover new methods for their subsequent transformation. In this proposal we will focus on the trapping of transient C(sp3)- and C(sp2)-Pd species via C-H activation, or employing oxygen/nitrogen ...
Palladium-Catalyzed Ring Restructuring Reactions of Oxazolidines for the Construction of Heterocyclic Compounds KU Leuven
Heterocyclic compounds is one kind of the most common and important organic molecules, which can be widely found in natural products, medicinal molecules and organic functional materials. At present, a lot of methods have been developed for the synthesis of heterocyclic compounds. Among them, ring restructuring reaction as an emerging popular strategy can provide a straightforward and efficient approach for the synthesis of heterocyclic ...
Electrocatalysis Mediated by Organopalladium Complexes Ghent University
The work describes the unique use of electrochemical energy (electrons) as reagents in chemical
reactions. This will be achieved through interactions with metal centers capable of accepting and
donating electrons. This ability to shuffle electrons at the metal center is the foundation of reactivity
of these metals enabling interactions with reagents that lead to bond forming events.
I will focus on a metal that is ...