Cell-based tissue-engineered reconstruction of large osteochondral defects in the minipig knee. KU Leuven
State of the art The availability of regenerative solutions for deep cartilage defects (osteochondral defects) in human joints is known as an unmet medical need. A long-term follow-up study from Mayoclinic recently demonstrated a significant higher risk of early osteoarthritis for knees with osteochondritis dissecans regardless if treatment was conservative or operative (1,2). The surgical treatment of these large osteochondral defects in ...