Projects
Building the human cornea on a chip. University of Antwerp
Fast scanning chip calorimetry combined with structural probes: on the role of metastable states in soft matter phase behavior. KU Leuven
Polymers, liquid crystals, gels, colloids and lipids are examples of soft matter, which all share the propensity to self-organize into mesoscopic physical structures. Little energy is often needed to convert one self-organized state to another, by which the structure and properties of soft matter can easily be altered by temperature or mechanical deformation. Under certain conditions, soft matter can take up multiple structures, of which only ...
Dynamic modelling of human progressive lung fibrosis in a human lung on chip KU Leuven
My research goal is to develop beyond state-of-the-art patient-derived complex cell models of interstitial lung diseases with progressive fibrosis (PF-ILD), amenable to precision medicine and implementation within drug discovery initiatives for better anti-fibrotic or disease modifying drugs. PF-ILD has a fatal outcome, with lung transplantation as only therapeutic option. Recent antifibrotic drugs can only slow down but not halt the disease. ...
Dynamic modelling of human progressive lung fibrosis in a human lung on a chip KU Leuven
Long-term storage of Organ-on-Chip: from deep space exploration to organ preservation on Earth KU Leuven
Space biological research studies the effects of the hostile space environment on the human body to enable future deep-space manned missions. As access to the ISS is limited, ground-based facilities are available on Earth to simulate different space stressors. Investigating the harmful effects of space on the human body is crucial to perform health risk assessments of astronauts during deep-space missions. Organ-on-chips (OoC) are complex 3D ...
Hardware-efficient spike sorting based on hybrid analog/digital computation KU Leuven
The brain is the most complex organ in the human body and, to be able to understand how it works, large-scale in-vivo sensing of neuron populations has emerged as a key research technique. Microfabricated silicon neural probes have established as the dominant technology in this field and have achieved ever increasing densities and numbers of simultaneous recording electrodes. Imec is the leader in the design and development of CMOS neural ...
A compact liver-on-a-chip read-out system: combining fluorescence and Raman imaging to monitor the impact of steatogenic drugs on the liver Vrije Universiteit Brussel
severe liver injuries relies on long-term pre-clinical animal testing.
Since the findings obtained from those tests do often not provide
sufficient information on how the drug will interact with the human
body, drug toxicity has already led to several interruptions of clinical
trials, post-market withdrawals and restricted use guidelines of ...
Lung-on-a-chip as a dynamic tool to capture interplay between airway and vascular cells in their microenvironment: a focus on the course of chronic obstructive pulmonary disease KU Leuven
Chronic obstructive pulmonary disease (COPD), which is estimated to become the third leading cause of death worldwide by 2030, is actually the only major disease whose prevalence and mortality are increasing worldwide in all continents. Despite intensive research, there are still unmet medical needs for this disease. Abnormal responses of the airway epithelium to the environmental triggers are believed to contribute to the pathogenesis of ...
Machine Learning Acceleration on Heterogeneous Platforms KU Leuven
Advances in the fields of biomedical sensors, wearables and medical implants, in combination with state-of-the-art algorithms from signal processing, machine learning and artificial intelligence, are transforming the healthcare landscape. Systems built around these technologies enable remote health monitoring, improve patient care, detect life-threatening conditions or even predict health events. Yet the full integration of such technologies ...