Our knowledge about genomes, epigenomes and transcriptomes is mainly obtained from the analyses of multiple cells together. However, such assays are averages and individual cellullar variation is lost. The possibility to sequence individual cells is reshaping our fundamental knowledge about normal development, ageing and diseases. This revolution is the basis for the erection of a single cell institute (SCI) at the KULeuven. This institute ...
Omics for PATHogenic Yeasts: OPATHY / Host pathogen interactions in Candida vaginitis as established with dual RNA sequencing Ghent University
OPATHY is an innovative translational research training network that will explore the potential of omics technologies, including genomics, transcriptomics and proteomics, to study the interactions of yeasts that cause disease to humans (e.g. Candida and C
Precision medicine in inherited blindness using integrated omics in human and animal models Ghent University
This multidisciplinary project aims (1) to decipher cis-regulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-based treatments of novel targets, ultimately resulting in precision medicine ...
Evolutionary, ecological and environmental omics. University of Antwerp
Taking ovarian cancer diagnosis to the next level: evaluation of the decision to operate, the added value of MRI and OMICS markers, and optimal integration to patient care pathways KU Leuven
"Integrated omics" vision to provide molecular insights in reproduction, developmental physiology, ecology and evolution of nematodes. University of Antwerp
Recent technological advances enable cost-efficient, high-throughput analysis of multiple biologic molecules and molecular interactions, which lead to a wealth of omics data: genome, epigenome, transcriptome, proteome, metabolome, ... The capacity to integrate multi-omics data, to something more than the sum of the existing data, is key to elucidating the causes of complex diseases such as neuro-inflammatory disorders and cancer. Multi-omics ...
Cross-omics data analyses and integration in precision health. Hasselt University
Preparative and analytical ultracentrifugation to aid integrative, multi-omics studies. Ghent University
While state-of-the-art omics-based analysis provide the opportunity to study macromolecules and their expression levels in detail, the enrichment of specific subsets (e.g. by means of ultracentrifugation) is indispensable for obtaining multidimensional (e.g. spatial) insights in OMICS data. Consequently, the ultracentrifuges will act as workhorses for the routine analysis of protein and translation complexes to advance our infection biology ...
Multi-omics data integration in the context of regulatory networks to decipher regulatory metabolites in complex diseases such as cancer and neuro-inflammatory disorders Ghent University
First, we will conduct a benchmarking of computational methods for multi-omics data integration. Next, we will develop an improved methodology for multi-omics data integration in the context of regulatory networks to gain in-depth mechanistic insights. Finally, we will apply our methodology to neuro-inflammatory disorders and cancer to identify novel regulators such as regulatory metabolites.