Projects
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Patient specific fluid structure interaction modelling of aortic coarctation. Pre- and post-operative numerical study of biomechanical loads and ultrasonic imaging of the pathological aorta. Ghent University
Department of Electronics and information systems, Department of Civil engineering, Department of Flow, heat and combustion mechanics
Aortic coarctation is a congenital narrowing of the descending aorta. As it obstructs blood flow, it needs to be treated as soon as possible (shortly after birth). The aim of this project is to find an optimal (patient-specific) treatment based on biomechanical loads calculated through fluid structure interaction. This project also focuses on quantifying wave reflections and imaging techniques such as MRI and 3D Ultrasound.
Arterial biomechanics in 4D: understanding the long-term effects of mechanical overload KU Leuven
Various surgical interventions, such as vascular clamping, balloon angioplasty, or stenting, induce mechanical overload to arterial tissue, often leading to tissue damage. This overloading and resulting damage triggers growth and remodeling processes in the tissue, causing changes in mass and microstructure. This can lead to healing of the tissue, but the remodeling processes can also cause maladaptation. It remains unclear what triggers ...
How does muscle fiber type distribution affect the biomechanics and energetics of locomotion. KU Leuven
Why do we, humans, move the way we do? Energy minimization is often assumed to be one of the major neuromuscular mechanisms underlying the preferred gait. Yet, why certain gait pattern appears optimal for a specific person is still a question. As skeletal muscles are the major energy consuming tissues during locomotion, it seems very likely that during this preferred gait pattern muscles operate at favorable conditions. Interestingly, muscles ...
Computational biomechanics as a tool for personalised medicine Ghent University
Throughout history, medicine has been largely built on statistical grounds, treating individual patients as members of (potentially heterogeneous) groups, which may result in suboptimal treatment outcomes. Ideally, the general focus should be shifted from the general approach towards a more personalised medicine. This research projectU+2019s ambition is to take part in this revolution by using computational biomechanics as a tool for ...
Head impact biomechanics for protecting the active ageing population KU Leuven
In Europe, the incidence of fatal and hospitalized traumatic brain injury (TBI) is 262/100.000/year. Lately, a significant increase in the proportion of elderly patients suffering TBI has been observed. This can be explained by changing demographics, better health status allowing them to remain fully active, but also by the presumed mechanical vulnerability of the ageing brain and surrounding tissues.
While staying active is rightfully ...
Biomechanics Ghent University
The AOG Biomechanics is doing experimental and computational research on (1) biofluid flows in the cardiovascular system, the pulmonary airways and artificial organs, (2) structural mechanics (musculoskeletal system or stent inflation in an artery) and (3) mechanical interaction between fluids and structures (e.g. heart valve dynamics). The research unit aims to optimize diagnostic methods and therapies, all for the benefit of human health. ...
Constitutive Modeling and Numerical Implementation of Brain Tissue Including Damage KU Leuven
Introduction:
Brain injury is one of the main causes of mortality and morbidity. Different types of Traumatic Brain Injury (TBI) are known where Ischemia is a common pathway. Elevated intracranial pressure (ICP) is associated with ischemia and poor outcome after TBI. The brain is consisted of different constituents such as cerebrospinal fluid (CSF), the porous solid tissue and the blood. The values of normal and raised ICP are given in ...
Tissue-Level Tolerance Criteria for Crash-Related Head Injuries: A Combined Experimental and Numerical Approach KU Leuven
Head injury (HI) is the fourth leading cause of death in the Western world and a major source of post-traumatic disability. It is the result of a fierce acceleration or an impact to the head, which can be caused by falls, vehicle accidents, accidental hits in sport and recreation, and assaults. Over the last decade, approximately 4 million people suffered yearly from Traumatic Brain Injury (TBI) in Europe. The epidemiology, social and ...
Numerical and experimental study of footbridge vibrations induced by running KU Leuven
Numerical and experimental study of footbridge vibrations induced by running The search for the perfect balance of financial, environmental and aesthetic aspects in designing modern footbridges has driven architects and engineers to conceive very slender and lightweight structures. However, this trend has resulted in structures to be increasingly sensitive to vibrations induced by walking and running pedestrians. Over the last two decades, ...