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Danio rerio: a “humanized” in vivo model for the study of non-cell autonomous mechanisms in ALS KU Leuven

Ludo Van Den Bosch
Molecular Biodiscovery, Laboratory for Neurobiology (VIB-KU Leuven)

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the loss of both upper and lower motor neurons (MNs). In this regard, in the last years the non-cell autonomous contribution of reactive astrocytes has been considered as extremely influential to the course of the pathology. Unfortunately, in-vitro 2D cultures and mouse models are not capable to fully recapitulate molecular pathological features and motor ...

Arginine depletion via Arginase-1 as a key mechanism of M2- macrophage-induced neuroprotection after spinal cord injury. Hasselt University

Sven HENDRIX
Immunology & Infection, Morphology
Worldwide, over two million people are affected by a spinal cord injury (SCI). This devastating disorder is a major cause of morbidity, mortality and reduced quality of life. Patients suffer from severe losses of motor, sensory and autonomic nervous system functions. Controlled immunomodulation therapy is the key goal to replace non-specific immunosuppression, which is still the state of the art intervention after SCI today. Pro-inflammatory M1 ...

Identification and functional analysis of extracellular RNAs in insects. KU Leuven

Jozef Vanden Broeck
Animal Physiology and Neurobiology
Several non-coding transcript species constitute an as yet underexplored layer of regulatory complexity. Various types of regulatory RNAs indeed appear to interfere with gene expression at different control levels. In insects, the largest and most diverse class of animals, the RNAi response, which is believed to play a role in antiviral immunity, appears to vary among species and tissues. Some species display a cell-autonomous response to dsRNA, ...