Projects
Exploring the neuro-immune mechanisms underlying nasal hyperreactivity in rhinitis and rhinosinusitis KU Leuven
Rhinitis can present with nasal obstruction, nasal discharge, itch, or sneezing. In case of involvement of the paranasal sinuses (i.e. rhinosinusitis), facial pain or loss of smell is possible as well. Several endotypes of rhinitis and rhinosinusitis are known, such as type 1 or type 2 inflammation.
Allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP) are both characterized by a mainly type 2 inflammation in the ...
Impact of epithelial barrier dysfunction on inflammation in allergic rhinitis KU Leuven
Patients with allergic rhinitis (AR) suffer from nasal obstruction, sneezing, rhinorrhea and itchy nose. Additionally, nasal hyperreactivity (NHR) is present in more than 60% of patients with AR. NHR is defined as the induction of nasal symptoms after exposure to non-specific triggers in the environment. Many patients with AR are not well controlled, with several unmet therapeutic needs.
The nasal mucosa the first line of defense ...