Projects
Population-based next generation sequencing to elucidate the complex genetics of Alzheimer dementia. University of Antwerp
Inherited predisposition for breast cancer in the next generation sequencing era: evaluation of the role of genes involved in homologous recombination and G2/M checkpoint control and decelopment of a functional assay. Ghent University
In less than 20% of the familial breast cancers a germline mutation in the major breast cancer genes BRCA involved in hte same pathway by a next generation sequencing approach. Furthermore, we will develop a functional assay to elucidate the role of variants of unknown significance.
Next generation sequencing to analyze the quasispecies evolution of influenza A virus in the immune host Ghent University
Next generation sequencing will be applied to study the evolution of the influenza A virus in the immune host. The aim of this research is to better understand how influenza viruses evolve under selection pressure of the vaccinated host.
Next generation Sequencing infrastructure Hasselt University
Pathofysiological characterization of megakarypoiesis using next generation sequencing KU Leuven
The main function of platelets is to reduce the blood loss after an injury. Platelets originates from MKs in a process called megakaryopoiesis. Defects in megakaryopoiesis can lead to a low platelet count (thrombocytopenia), which can cause severe bleeding problems. Understanding the underlying mechanisms of megakaryopoiesis is crucial to improve medical treatment and identify novel therapeutic targets. This PhD project focused on gaining ...
Identification of a novel disease causing gene for osteopetrosis using next generation sequencing technology. University of Antwerp
Deciphering the molecular pathogenesis of neuroblastoma through next generation genome analysis Ghent University
In this project, the newest technologies in human genetics (massively parallel sequencing and ultra-high throughput qPCR) will be used to better understand the molecular mechanisms causing neuroblastoma, a highly lethal pediatric malignancy, with perspectives for development of targeted therapies.