Projects
Shining new light on G protein-coupled receptors by combining of a new class of sensors with tailored high-resolution fluorescence microscopy. KU Leuven
G protein-coupled receptors (GPCRs) are the ears and eyes of the cell. Encoded by more than 800 genes on the human genome and target for more than 30% of the marketed drugs, they sense extracellular information and translate it to intracellular action. The vast importance of these receptor molecules has resulted into a wealth of information on how they work and communicate with the cellular machinery. However, while new insights emerge on ...
NEW ANAESTHETIC STRATEGIES FOR PAEDIATRIC AND FOETAL INTERVENTIONS TO IMPROVE HAEMODYNAMIC STABILITY AND NEUROCOGNITIVE OUTCOME KU Leuven
General anesthesia in young children has reached such a level of safety in terms of immediate outcome that indications are growing disproportionally. General anesthesia is increasingly used to provide not only ideal and safe conditions for invasive surgical interventions, but also for diagnostic and interventional procedures. With the advances in prenatal diagnosis and therapy, the indications for fetal surgery continue to expand, and ...
MOLECULAR EVOLUTION OF A NEW EBOLA VIRUS STRAIN AND ANALYSIS OF KIR GENE VARIANTS IN EBOLA VIRUS DISEASE KU Leuven
Ebolaviruses are emerging viruses that pose a significant threat to wildlife populations and to public health in Africa. Of the six viral species of the genus Ebolavirus, three can cause severe and fatal diseases in humans: Zaire ebolavirus, Sudan ebolavirus and Bundibungyo ebolavirus. Although Zaire ebolavirus (EBOV) is known to be the deadliest species, some EBOV-infected individuals can completely resist ...
Towards new therapeutic areas for HDL-targeted interventions KU Leuven
Characterization of occurrence, metabolism and contribution to human exposure of new chemicals present in the indoor environment. University of Antwerp
Design and development of a new vector platform for CXCR4-targeted molecular imaging and radionuclide therapy KU Leuven
The CXC chemokine receptor 4 (CXCR4) is a well-described G protein-coupled receptor (GCPR) that is involved in different physio-pathological processes upon binding of its endogenous ligand CXC chemokine 12 (CXCL12). CXCR4 is expressed throughout development and adulthood on a variety of cell types including lymphocytes, endothelial, epithelial and hematopoietic stem cells (HSCs). CXCR4 plays a fundamental physiological role in hematopoiesis, ...
Caring with matter: towards new artistic forms of togetherness Hasselt University
Caring with matter: towards new artistic forms of togetherness KU Leuven
Humanity’s facing extinction as a consequence of its exploitative activities towards the nonhuman world calls for new possibilities of survival and the rethinking of our relation to the nonhuman. I propose that an artistic practice that acknowledges and explores the affective dimension of human and nonhuman relations will allow for a novel perspective. In fact, guided by empathy, shared vulnerabilities between human and nonhuman entities will ...