Investigating the role of astrocytes and noradrenaline as critical regulators of neuronal circuit excitability. KU Leuven
Proper information processing in the mammalian brain requires tight
regulation of neuronal excitability, which can be modified by so-called
neuromodulators, such as noradrenaline. Noradrenaline (NA) is
known to prime the healthy brain for sensory input and to facilitate
memory formation. However, hyperactivity of neurons is deleterious
and can lead to disease, of which the classic example is epilepsy.
Crucially, ...