Projects
The effect of Alzheimer's disease on cognitive decline after an ischemic stroke and the role of neurogenesis. University of Antwerp
IGF-2 and Des(1-6)IGF-2 as new tools to boost neurogenesis after ischemic stroke. Hasselt University
IGF-2 and Des [1-6] IGF-2 as new tools to boost neurogenesis after ischemic stroke. Hasselt University
IGF-2 and [DES-1-6]IGF-2 as new tools to boost neurogenesis after ischemic stroke Hasselt University
Role of vascular endothelial growth factor (VEGF) -isoforms in pathological retinal angiogenesis and neurogenesis. KU Leuven
Deciphering the mechanisms underlying neurogenesis defects in mitochondiral diseases KU Leuven
Mitochondrial dysfunction can result in various forms of neurodevelopmental diseases (NDD), from microcephaly to intellectual disability. This suggests important roles for mitochondria in neural development, but these have remained poorly known, as their links with diseases. We recently showed that mitochondria dynamics play a key role in neurogenesis of mouse and human NSPCs of the cerebral cortex (Iwata et al. Science 2020). We ...
Regulatory Roles of Mitochondria and Metabolism in Neurogenesis KU Leuven
Neurogenesis is a key event of neural development, by which neural stem/progenitor cells (NSPC) stop self-renewing and dividing, to convert to postmitotic neurons. The delicate balance between self-renewal and differentiation of NSPC is controlled by intrinsic and extrinsic cues, in particular transcription factors and morphogen signals (Bonnefont and Vanderhaeghen, 2021; Villalba et al., 2020)). On the other hand, recent evidence have ...
Study of the role of adult neurogenesis in the olfactory bulb by optogenetic neuromodulation. KU Leuven
It is established that neurogenesis persists in the adult brain of all mammals including humans. Interestingly, this phenomenon is restricted to two specific brain areas consisting of the subventricular zone (SVZ) of the lateral ventricles and the dentate gyrus of the hippocampus (HC). The existence of adult neurogenesis throughout adult life created the hope for brain repair by cell replacement of the cells lost during neurodegenerative ...