Projects
European Training in Neural Regulation of Intestinal Function. KU Leuven
Neurogastroenterology is a new and emerging medical/scientific subspecialty that currently has no formal training opportunities in medicine and related disciplines. It includes basic science aspects (neurophysiology, neurobiology, neuropsychology, psychophysiology) and clinical aspects (gastroenterology, neurology, internal medicine, surgery, psychology, psychosomatic medicine) of the neural control of intestinal functions (motility, ...
Prenatal adeno-associated viral transduction of the enteric nervous system as a novel toolbox in neurogastroenterological research. University of Antwerp
ADAPT: Adaptive and predictive arbitrary point scanning two photon tomography KU Leuven
Two photon (2P) microscopy is an ideal technique to image deep inside tissues and organisms, with good sub-cellular axial resolution and without causing tissue damage. These advantages make 2P microscopy suited for intravital imaging, which can be used to investigate how neuronal circuits operate in normal and fail in diseased conditions. However, the current recording speeds of 2P microscopy are a limiting factor. They do not allow imaging ...
MicroRNA regulation of enteric glia phenotype and function Hasselt University
Gut-organ axes in health and disease Hasselt University
Coordination of intrinsic neural network connectivity in the gut by enteric glial DISC1 Hasselt University
Proteases as novel target to treat visceral hypersensitivity KU Leuven
Up to 20% of individuals in the world population suffer from irritable bowel syndrome (IBS). IBS is a gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits, such as constipation or diarrhoea. It is now well established that abdominal pain in IBS patients is caused by sensitization of ion channels in sensory nerve fibres, leading to visceral hypersensitivity. We have recently identified histamine as a major ...