Unravelling early cell fate decisions during human preimplantation development KU Leuven
The lineage segregation events during early embryonic development are coordinated by the dynamics of extracellular signals. They assure the correct specification of the inner cell mass (ICM), giving rise to the embryo proper, and the primitive endoderm (PrE), contributing to extra-embryonic tissues, in the epiblast (Epi). Despite the great importance of the Epi/PrE lineage segregation during early embryonic development, the lack of suitable ...