Projects
Hepatic toxicity modeling and prediction: focus on drug-induced cholestasis Vrije Universiteit Brussel
These virtual research groups are established with the help of efficient coordination and intensive collaboration at (inter) national level. They prevent double use and offer researchers more development ...
TRP channel sensitization as target for treatment of hypersensitivity (TRP-sensation). University of Antwerp
Innovation Centre-3Rs Symposium 2023: ‘Emerging fields in 3Rs’ Vrije Universiteit Brussel
Chemogenetic modulation of CX3CR1+ cells in a mouse model of drug-resistant limbic epilepsy. Vrije Universiteit Brussel
epilepsy with a high unmet medical need. Microglia, the brain
resident CX3CR1+ macrophages, are in close interaction with
neuronal cells, both via indirect (e.g. release of soluble mediators
such as inflammatory cytokines) and direct (e.g. synaptic pruning)
contacts. Both modes of gliocommunication seem able to alter the
excitatory/inhibitory ...
Neural mechanisms of adaptation in inferior temporal cortex: an optogenetic and pharmacological analysis. KU Leuven
Neurons in sensory brain areas change their responses to a stimulus after being exposed recently to that stimulus. This “adaptation” is a kind of short-term plasticity of the brain. Adaptation effects vary amongst brain regions and range from a suppression of the response to a repeated stimulus (“repetition suppression”) to an enhancement of the response to repeated stimuli. Repetition suppression is prominent in the inferior temporal (IT) ...
Direct detection and identification of neuro-oncology markers in brain tumours KU Leuven
The outcome for brain cancer patients is highly dependent on the maximal removal of tumour tissue, but the quality of life post-surgery is linked to the precision by which non-tumoural, essential parts of the brain can be preserved. Today, the decision between removing and partly leaving tissue during surgery is based on a combination of MRI-neuro-navigation guidance, the use Gliolan®, a fluorescent dye that highlights tumour cells, ...
Are connexin hemichannels and pannexin channels therapeutic drug targets and diagnostic biomarkers in cholestasis? Vrije Universiteit Brussel
Physiological and molecular-genetic characterisation of the neuropeptide SIFamide in Caenorhabditis elegans . KU Leuven
Highly efficient non-Euclidean optimization and MCMC methods for deep matrix completion KU Leuven
The matrix completion (MC) problem is of interest in many applications, especially in bioinformatics, chemoinformatics, and systems biology. The existing methodologies for dealing with MC problems are based on the linear dependency between the data entries that factorize the matrix into two (or more) low-rank matrices. Moreover, due to the sparsity and scarcity of the entries of the data matrix, MC suffers from unavoidable large ...