In-depth comparison and feasibility assessment of an integrated pipeline for neoantigen identification and HLA ligandome sequencing in a clinical setting Ghent University
Each year 4500 individuals are diagnosed with lung cancer in Flanders alone. Five years later, 85% of these individuals will have died despite intensive treatment. Moreover, current treatments are either highly toxic or susceptible to rapid development of resistance. Recently however, a new therapy was discovered: immune checkpoint blockers (ICB), which prevent the downregulation of the natural immune activity towards cancer cells. Despite ...