Projects
NANOSTEM: An in-depth mechanistic study on how NANOparticles interfere with cell cycle dynamics and developmental processes in STEM cells Hasselt University
Process Intensification in the Reactive Crystallization of Micro- and Nanoparticles KU Leuven
Study of the ultrasound effects on the micro- and nanoparticle synthesis of zeolites at lab scale. For a broad range of temperatures (50-150 °C) and pressures (1-10 bar) US frequency and power are studied for: 1) efficient mixing prior/during crystallization of micro- and nanoparticles, and for 2) de-agglomeration of the crystal aggregates. Micromixing studies are undertaken, as well as the evaluation of meta-stable zone width, induction time ...
Perturbing tumor-associated macrophage (TAM) equilibrium using GPNMB/CD206 nanobodies and nanoparticles in breast cancer. Ghent University
Nanobodies are highly attractive to promote better active nanocarrier targeting, while M2-TAMs (tumor-associated macrophages) dominate the tumor microenvironment (TME) resulting in a worse treatment of breast cancer. Hence, there is a clear need to develop novel strategies to perturb TAM equilibrium. This project will use GPNMB/CD206-targeted nanobodies and nanoparticles to reveal the specific pathways for M2-TAMs re-education.
Exploring co-encapsulation of antihistamines and immune checkpoint siRNAs in lipid nanoparticles for cancer immunotherapy. Ghent University
Our group recently showed that cationic amphiphilic drugs (CADs) can complex nucleic acids in lipid nanoparticles (LNPs) for drug combination therapy. This project aims to evaluate this CAD-LNP platform in cancer immunotherapy. Immune checkpoint blockade (ICB), e.g. via PD-L1 antibodies, has demonstrated clinical efficacy, but is hampered by immune-related off-target effects following systemic exposure and low response rates due to an ...
Design and Synthesis of Multifunctional PPV-Based Nanoparticles for Multiple Sclerosis Research Hasselt University
removal of micropollutants from water using a combination of electrochemical sorption/desorption and biogenic nanoparticles. Ghent University
in this research, a technology will be developed for the effective treatment of water containing micropollutants. This technology will consist of a combination of a preconcentration step by electrochemical sorption/desorption and a degradation using biogenic nanoparticles as catalysts. The activity of the nanoparticles will be maximized bij an in-dept study of their structure and their structure-activity relationship.
Towards a cure for deafness in DFNA9: loading lipid nanoparticles with CRISPR-Cas9 to safely target dominant-negative mutations in the COCH gene in vitro and in vivo. University of Antwerp
Quantitative in-situ structural, morphological and compositional characterization of bimetallic nanoparticles as a route towards innovative electrocatalysts. University of Antwerp
Synthesis and Formulation of nanoparticles for pinning in YCBO coated conductors Ghent University
The main research objective is the formulation of new types of multimetaloxide nanocrystals for incorporation as artificial pinning centers in nanocomposite thin films processed using chemical solution deposition. Superconducting coated conductors are chosen as the proof of concept. Innovative chemical deposition methods and the incorporation of preformed and inert multimetaloxide nanocrystals as pinning centres into the superconducting ...