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Muscle fibre capillarization is a critical factor in muscle fibre hypertrophy during resistance exercise training in older men Vrije Universiteit Brussel
BACKGROUND: Adequate muscle fibre perfusion is critical for the maintenance of muscle mass; it is essential in the rapid delivery of oxygen, nutrients and growth factors to the muscle, stimulating muscle fibre growth. Muscle fibre capillarization is known to decrease substantially with advancing age. However, whether (relative) low muscle fibre capillarization negatively impacts the muscle hypertrophic response following resistance exercise ...
Skeletal Muscle Fibre Characteristics of the Lumbar Multifidus Muscle in Patients Undergoing Microdiscectomy for Unilateral Lumbar Disc Herniation Hasselt University
Background. Lumbar disc herniation (LDH) is the most common diagnosed degenerative pathology in the lumbar spine. Because of its role in spinal stability there is an increased interest in the role of the Lumbar Multifidus muscle in low back pain research. Despite surgical treatment long-term, disability and pain remain a persistent problem. The aim of the study is to compare side-to-side Lumbar Multifidus muscle fibre characteristics in ...
Muscle fibre typology affects whole-body metabolic rate during isolated muscle contractions and human locomotion. KU Leuven
The wide variation in muscle fibre type distribution across individuals, along with the very different energy consumption rates in slow versus fast muscle fibres, suggests that muscle fibre typology contributes to inter-individual differences in metabolic rate during exercise. However, this has been hard to demonstrate due to the gap between a single muscle fibre and full-body exercises. We investigated the isolated effect of triceps surae ...
Hamstring muscle fibre typology is not associated with hamstring strain injury history or performance in amateur male soccer players : a retrospective magnetic resonance spectroscopy study Ghent University
Hamstring strain injuries (HSI) are still the most common injuries in soccer. Recent research has been focusing on the role of hamstring muscle morphology and architecture. The hamstring’s fibre type composition might play a role as well, but this has never been investigated in the light of HSI risk in an athletic population. The purpose of this study was to investigate the association between hamstring muscle fibre type, hamstring strain injury ...
Altered fast- and slow-twitch muscle fibre characteristics in female mice with a (S248F) knock-in mutation of the brain neuronal nicotinic acetylcholine receptor KU Leuven
We generated a mouse line with a missense mutation (S248F) in the gene (CHRNA4) encoding the alpha 4 subunit of neuronal nicotinic acetylcholine receptor (nAChR). Mutant mice demonstrate brief nicotine induced dystonia that resembles the clinical events seen in patients with the same mutation. Drug-induced dystonia is more pronounced in female mice, thus our aim was to determine if the S248F mutation changed the properties of fast- and ...
The effect of mutations in the insulin-like growth factor-II and ryanodine receptor-1 genes on biochemical and histochemical muscle fibre characteristics in pigs KU Leuven Ghent University
Mutations in IGF-II (insulin-like growth factor-II) and RYR1 (ryanodine receptor-1) increase lean meat content in pigs but with different effects on meat quality. Differences in biochemical and histochemical muscle fibre characteristics between the two mutations can thus be suspected. Therefore, the aim of this study was to investigate the effect of the IGF-II mutation (Apat vs. Gpat) on biochemical and histochemical muscle fibre characteristics ...
Recessive MYL2 mutations cause infantile type I muscle fibre disease and cardiomyopathy KU Leuven
A cardioskeletal myopathy with onset and death in infancy, morphological features of muscle type I hypotrophy with myofibrillar disorganization and dilated cardiomyopathy was previously reported in three Dutch families. Here we report the genetic cause of this disorder. Multipoint parametric linkage analysis of six Dutch patients identified a homozygous region of 2.1 Mb on chromosome 12, which was shared between all Dutch patients, with a log of ...
Feasibility, accuracy and safety of a percutaneous fine-needle biopsy technique to obtain qualitative muscle samples of the lumbar multifidus and erector spinae muscle in persons with low back pain Hasselt University
The lumbar muscular system, in particular the lumbar multifidus muscle (LM) and the erector spinae muscle (ES), plays an important role in stabilizing and mobilizing the lumbar spine. Based on the topography, the lumbar paraspinal muscles can be classified into local and global muscles. LM is part of the local system, whereas ES is part of the global system. Therefore, it is interesting to investigate the muscle fibre type composition in both ...
Fibre type composition in the lumbar perivertebral muscles of primates: implications for the evolution of orthogrady in hominoids Royal Zoological Society of Antwerp University of Antwerp KU Leuven
The axial musculoskeletal system is important for the static and dynamic control of the body during both locomotor and non-locomotor behaviour. As a consequence, major evolutionary changes in the positional habits of a species are reflected by morpho-functional adaptations of the axial system. Because of the remarkable phenotypic plasticity of muscle tissue, a close relationship exists between muscle morphology and function. One way to explore ...