Projects
Methods for Integrated analysis of Mulptiple Omics datasets : MIMOmics Hasselt University
Integration of complementary, high throughput single-cell omics with spatial resolution. KU Leuven
The human body is composed of millions of cells. Large efforts aiming at describing every cell in the human body have recently started with the aim to revolutionize healthcare. Understanding health and diseases requires methods that examine individual cells in their natural microenvironment, assess their spatial distribution in the tissue, both bi- and tri-dimensionally, and that capture and integrate multiple layers of information including ...
New kids on the block: Improving the care of people with multiple sclerosis by introducing "RADIOMICS" and "EPOMICS". Hasselt University
In situ, spatially resolved 'omits' at the single cell level, unlocked through expansion microscopy KU Leuven
Cells are the fundamental functional units in all forms of life. Even though largely
all cells in a human body carry the same genetic information, we still know
surprisingly little about their detailed composition. This is due to the vast
amount of variation in a cell’s gene expression. Specifically, each cell at a certain
moment in time has a certain set of genes that are switched on or off, resulting
in different ...
Development of highly multiplexed and ultra-sensitive spatial (multi-)omics assays to disclose and understand the biology of cellular heterogeneity in pre- and post-implantation embryogenesis at the single-cell level KU Leuven
Following fertilization, instigation of cellular heterogeneity amongst genetically identical cells is an important process of cell lineage specification and proper development of the embryo. However, these earliest phases of life remain poorly understood as methods for single-cell sequencing have low molecular sensitivity, suffer technical noise, and loose spatial cellular and molecular information obstructing fundamental insight in cell-cell ...
Translational research in neurodegenerative dementia and related disorders. University of Antwerp
Tool development for multi-omic data integration KU Leuven
Pathology plays a major role in determining the treatment that a cancer patient will receive. Over the past years, single-cell analyses are revealing tumors as complex cellular mixtures, for which the next challenge is focused on investigating how all these cells interact in specific microenvironments. Novel technology platforms, including multiplexed IHC (mIHC) and spatial transcriptomics, are rendering such high-dimensional analysis ...
Resolving cellular heterogeneity and cooperation in human health and disease using highly multiplexed spatial (multi-)omics technologies KU Leuven
The current PhD project is placed in the context of a KU Leuven interdisciplinary network (IDN) project, focused on the development and application of a spatial single-cell multi-omics platform to study cellular heterogeneity and cell-cell cooperation in human tissues and organs in health and disease. The project will focus on developing, implementing and running complex molecular biology methods for in situ profiling of RNA molecules in ...