Multi-dimensional investigation of mobility related fatigability in persons with multiple sclerosis, and effects of cognitive-motor interventions. Hasselt University
Somatic mutations explain missing risk in multiple sclerosis
An Goris, Laboratory for Neuroimmunology, KU Leuven
1. State of the art
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, affecting 2.5 million
people worldwide and leading to important physical and cognitive disability with typical onset during
young adulthood. A genetic component has long been demonstrated and through ...
Immune regulation by dimethylfumarate (DMF) in patients with relapsing-remitting multiple sclerosis Hasselt University
Long‐term functional re‐myelination and neuroprotection via a multi‐modal biomaterial system studied in vivo in a mouse model of Multiple Sclerosis (MS). University of Antwerp
Development of Hydrophobic Hydrogels to Induce Remyelination of Myelin Sheaths for Multiple Sclerosis treatment Ghent University
Multiple sclerosis is a disease resulting from the damage of myelin sheath wrapping the axon in the nerve cell. This damage leads to slow down of the nerve impulses through the axon. Therefore, the use of hydrophobic hydrogels based on biocompatible monomers could provide a scaffold that induces myelin sheath regeneration as potential first step towards treatment of multiple sclerosis.
Inflammatory signaling pathways are subjected to tight regulation to avoid chronic inflammation and the development of inflammatory pathology. One of the proteins involved in such regulation is the deubiquitinating enzyme OTULIN. In my PhD, I aim to investigate the role of OTULIN in central
nervous system inflammation and in models of multiple sclerosis and Alzheimer pathology.