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Tournesol 2009: project T2009.20: Glycine system ans microglia in normal brain and Multiple Sclerosis Hasselt University

In this project we want to study the role of glycine in function of macrophages and microgliale cells in physiological conditions (development of inhiberedende neurotransmission) and in the pathological context (multiple sclerosis). This project consists of 2 parts: In a first part, we will use in vitro models (primary cultures and macrophage / microgliale cell lines) to study glycine and its targets (GlyR, GlyT, as well as synthesis and ...

Multi-dimensional investigation of mobility related fatigability in persons with multiple sclerosis, and effects of cognitive-motor interventions. Hasselt University

Peter FEYS

Rehabilitation Research Center

Multiple sclerosis (MS) is a disease characterized to induce several symptoms, including fatigue. Fatigue is highly prevalent in people with MS (pwMS), being one of the most debilitating symptoms reported by this population (e.g., almost 90% experience or have experience fatigue due MS). In the same line, fatigability, which is defined as a decrement on performance in a given task, is also higher prevalent in pwMS and affects both motor and ...

Somatic mutations explain missing risk of multiple sclerosis. KU Leuven

An Goris

Laboratory for Neuroimmunology

Somatic mutations explain missing risk in multiple sclerosis

An Goris, Laboratory for Neuroimmunology, KU Leuven

1. State of the art

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, affecting 2.5 million

people worldwide and leading to important physical and cognitive disability with typical onset during

young adulthood. A genetic component has long been demonstrated and through ...

Immune regulation by dimethylfumarate (DMF) in patients with relapsing-remitting multiple sclerosis Hasselt University

Veerle SOMERS

Immunology - Biochemistry

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that is characterized by an imbalance in the immune response, leading to a proinflammatory status. The disease has a prevalence of 1-2.5 million people worldwide, but there is no cure available. The pathogenesis is characterized by inflammation and oligodendrocyte loss, which leads to multifocal demyelination and neurodegeneration. Dimethylfumurate ...

Long‐term functional re‐myelination and neuroprotection via a multi‐modal biomaterial system studied in vivo in a mouse model of Multiple Sclerosis (MS). University of Antwerp

Marleen Verhoye

Bio-Imaging lab

Multiple sclerosis (MS) is a neurodegenerative autoimmune disease affecting the central nervous system (CNS). The damage caused to the neurons disrupts the ability of parts of the nervous system to transmit signals, resulting in a range of signs and symptoms, including physical, mental, and, sometimes, psychiatric problems. There is increasing evidence that a combination therapy will be necessary to achieve a significant slowing of MS ...

Development of Hydrophobic Hydrogels to Induce Remyelination of Myelin Sheaths for Multiple Sclerosis treatment Ghent University

Richard Hoogenboom

Department of Organic and Macromolecular Chemistry

Multiple sclerosis is a disease resulting from the damage of myelin sheath wrapping the axon in the nerve cell. This damage leads to slow down of the nerve impulses through the axon. Therefore, the use of hydrophobic hydrogels based on biocompatible monomers could provide a scaffold that induces myelin sheath regeneration as potential first step towards treatment of multiple sclerosis.

OTULIN in neuroinflammation, multiple sclerosis and Alzheimer pathology Ghent University

Geert van Loo

Department of Biomedical molecular biology

Inflammatory signaling pathways are subjected to tight regulation to avoid chronic inflammation and the development of inflammatory pathology. One of the proteins involved in such regulation is the deubiquitinating enzyme OTULIN. In my PhD, I aim to investigate the role of OTULIN in central
nervous system inflammation and in models of multiple sclerosis and Alzheimer pathology.

Towards an Off-the-Shelf Therapy: Tolerogenic Dendritic Cell-derived Extracellular Vesicles for the Treatment of Multiple Sclerosis. University of Antwerp

Nathalie Cools

Laboratory for Experimental Hematology (LEH)

MS is a chronic auto-immune disorder of the central nervous system (CNS) and the leading cause of non-traumatic disabling disease in young adults. Although the exact cause of MS remains to be elucidated, it is currently accepted that both genetic and environmental factors affect complex immunological responses, both in the periphery and the CNS. To date, there is still no cure for MS, but several immune-modifying and/or -suppressive treatments, ...

Empirical development of a multimodal prognostication tool to guide treatment-strategy for Multiple Sclerosis Hasselt University

Bart VAN WIJMEERSCH

Immunology & Infection, Rehabilitation Research Center, Noorderhart Revalidatie & MS

Multiple Sclerosis (MS) is an autoimmune neurodegenerative disease of the central nervous system. It is crucial to halt disease progression early to prevent long-term disability. Two treatment strategies are used: a classical escalation (starting first line agents) and an induction (starting high-efficacy drugs) approach. The therapy decision is often only based on clinical disease activity; however, subclinical disease can cause a patient to ...

Adipose tissue-resident Th cells modulate the adipose tissue-brain axis in multiple sclerosis Hasselt University

Bieke BROUX

Immunology & Infection, Maastricht University

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder of the brain. One known risk factor for developing MS is obesity. This common health condition leads to a chronic inflammatory state in adipose tissue (AT). However, the link between obese AT and MS remains elusive, but inflammatory processes in AT are likely to be involved. I hypothesize that AT-resident T helper (Th) cells, mediate the increased obesity-related MS ...

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