Fund Walter Pyleman & Fund Cremers-Opdebeeck: "Expanding the TDP-43 proteinopathy spectrum from the neuron to the muscle: a clinical, genetic, pathological and multi-omics study paving the way for new therapeutic strategies" Ghent University
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are incurable conditions characterized by the progressive loss of muscle strength and early-onset dementia, respectively. One thing these conditions have in common is the presence of aggregates of the protein TDP-43 in dying neurons. Since mutations in TDP-43 can cause ALS, the TDP-43 aggregates are believed to be the driving force of the progressive loss of neurons. Our ...