3D genome topology and multi-omics in granulosa cells to decipher the regulation of FOXL2, a key factor in ovarian development and maintenance Ghent University
FOXL2 is a key transcription factor in ovarian development and maintenance throughout life. Despite advanced knowledge about its role, its transcriptional regulation in the ovary is poorly understood. Most of the insights into FOXL2 regulation come from non-coding genetic defects we found in blepharophimosis syndrome (BPES), a rare, autosomal dominant syndromic form of primary ovarian insufficiency (POI), and from a goat and mouse model. We ...